The PCINJSKI District expands in the southern parts of the Republic.
It encompasses the municipalities of:

• Bosilegrad

• Bujanovac

• Presevo

• Surdulica

• Trgoviste

• Vladicin Han

• Vranje

Its seat is in the city of Vranje. It has a population of 243,529.

The Vranjaska Spa plays a particular part in this region, with its multi-medicinal thermal mineral waters.

The economy of Vranje is based on industry, mining, building industry, trade, agriculture, and forestry. The best known are tobacco factory and holding companies in textile and furniture industry.